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US 21 in South Carolina

York County SC

US 21 is multiplexed with I-77 when it enters South Carolina.

Fort Mill SC

Fort Mill SC

US 21 is primarily a two-lane highway through South Carolina.

South Carolina

Columbia SC

South Carolina

South Carolina

Beaufort County SC

Beaufort County SC

Continue:

North
US 1
South Carolina
US 17
South Carolina
North Carolina
US 21
Amtrak Palmetto
Yemassee
Amtrak Silver Meteor
Yemassee
Denmark
Amtrak Silver Star
Camden

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